锦鲤求职岗位描述
岗位简介
1、 样品分析与纯化：从事小分子及生物大分子（包括寡合苷酸、多肽、ADC/AOC类药物等）的分析与分离纯化工作；
2、 检测与方法开发：通过分析仪器进行定量与定性检测，完成分析与纯化方法的开发、验证及制备纯化工作；
3、 杂质与结构研究：参与分析及纯化平台搭建与优化，对样品杂质谱进行分析和杂质结构进行鉴定；
4、 前沿技术的应用：岗位有机会接触先进技术平台，引领药物发现的新趋势。
Job Description
1. Sample Analysis and Purification: Engage in the analysis, separation, and purification of small molecules and biomacromolecules (including oligonucleotides, peptides, ADC/AOC drugs, etc.);
2. Detection and Method Development: Perform quantitative and qualitative testing using analytical instruments; complete the development, validation, and preparative purification of analytical and purification methods;
3. Impurity and Structural Research: Participate in the establishment and optimization of analysis and purification latforms; analyze sample impurity profiles and identify impurity structures;
4. Application of Cutting-edge Technologies: The role provides opportunities to engage with advanced technology latforms and lead new trends in drug discovery.
工作职责：
1、分析方法与纯化方案开发：负责小分子及生物大分子（如寡核苷酸、多肽、ADC/AOC药物等）样品的分析与纯化方法开发，制定合理、高效的纯化方案；
2、制备纯化：运用Prep-RP、SEC、HIC、IEC、AC等多种分离技术，为药物化学、合成化学及化合物库提供的混合物以及生物大分子进行制备纯化；
3、分析与手性分离服务：提供专业、快速的手性分析/分离服务；熟练使用HPLC、UPLC、LC-MS、GC、GC-MS、IC、ICP-MS、HR-MS等多种分析方法，为药物化学、合成化学和发现过程化学提供客观、准确、及时有效的分析数据；
4、质量检测与结构鉴定：对纯化后的样品进行质量检测与分析；利用NMR、IR、HR-MS等常用结构鉴定手段，对目标产物及杂质进行结构解析与鉴定；
5、平台建设与项目管理：拓展完善现有技术平台与方法，提升团队技术实力；管理项目进程，加强沟通汇报及跨部门密切合作，确保按时高质量交付；
6、实验室日常运维：参与实验室日常运维和管理，包括试剂采购、工作分配、仪器设备定期维护及小故障排除、起草设备SOP等；持续总结与优化实验室操作规程，不断提高效率与规范程度；
7、工作汇报：根据公司要求，及时总结工作并完成实验研究报告。
Job Responsibilities:
1. Method Development & Purification Scheme Design: Responsible for analytical and purification method development for small molecules and synthetic biomacromolecules (such as oligonucleotides, peptides, ADC/AOC drugs, etc.), designing reasonable and efficient purification schemes.
2. Preparative Purification: Perform preparative purification for crude mixtures from Medicinal Chemistry, Synthetic Chemistry, and Compound Libraries, as well as biomacromolecules,using various separation techniques such as Prep-RP, SEC, HIC, IEC, and AC.
3. Analysis & Chiral Separation Services: Provide professional and rapid chiral analysis/separation services; proficiently use various analytical methods such as HPLC, UPLC, LC-MS, GC, GC-MS, IC, ICP-MS, HR-MS to provide objective, accurate, and timely analytical data for Medicinal Chemistry, Synthetic Chemistry, and Discovery Process Chemistry.
4. Quality Control & Structural Elucidation: Conduct quality testing and analysis of purified samples; utilize common structural identification methods such as NMR, IR, HR-MS to perform structural elucidation and identification of target products and impurities.
5. Platform Construction & Project Management: Expand and refine existing technology platforms and methods
to enhance team technical strength; manage project progress, strengthen communication, reporting, and close cross-departmental cooperation to ensure timely, high-quality delivery.
6. Daily Laboratory Operations: Participate in daily lab operations and management, including reagent procurement, task allocation, regular instrument maintenance, troubleshooting of minor issues, and drafting equipment SOPs; continuously summarize and optimize laboratory operating procedures to constantly improve efficiency and standardization.
7. Work Reporting: Summarize work timely according to company requirements and complete experimental research
reports.
任职要求：
一、 学历与专业背景
1、天然产物化学、药物化学、分析化学、生物化学、生物工程、生物技术、生药学等相关专业博士学历；
2、 具备良好的分析化学、有机化学及生物化学基础，英语六级（CET-6）或具备同等优秀的英语听说读写能力。
二、 核心专业技能
1、 分离纯化：熟悉色谱纯化原理、技术手段与方法开发思路，包括但不限于SEC、HIC、IEC、RP、AC、超滤、电泳、介质填料等；有抗体偶联药物（ADC/AOC）、寡核苷酸、多肽或小分子纯化经验者优先；
2、 仪器操作：熟练使用Prep-HPLC、Flash、LC-MS、蛋白纯化仪等仪器设备；
3、 分析检测：熟悉生物/化学分析检测方法（如LC-MS/TOF/Q-TOF、HPLC、UPLC、GC等），具备独立设计实验方案与开展项目的能力；
4、 结构鉴定：熟悉常用结构鉴定手段（如IR、HR-MS、NMR等），能对目标产物及杂质进行解析。
三、 综合素质与软技能
1、 具备良好的项目管理能力、责任心、团队合作精神、创新意识及严格的保密意识；
2、 具备优秀的沟通协调能力和英文基础；
3、 为人诚实勤奋，执行力强，有进取心，能承担挑战并善于调节压力，能适应快速的工作节奏及较强的工作压力；
4、 严格遵守相应的安全规定及制度。
Job Requirements
I. Education & Professional Background
1. PhD in Natural Product Chemistry, Medicinal Chemistry, Analytical Chemistry, Biochemistry, Bioengineering, Biotechnology, Pharmacognosy, or a related field.
2. Solid foundation in analytical chemistry, organic chemistry, and biochemistry. CET-6 certified or equivalent
excellent proficiency in English (listening, speaking, reading, and writing).
II. Core Technical Skills
3. Separation & Purification: Familiar with chromatographic purification principles, techniques, and method
development strategies, including but not limited to SEC, HIC, IEC, RP, AC, ultrafiltration, electrophoresis, and chromatographic media. Experience in the purification of antibody-drug conjugates (ADC/AOC), oligonucleotides, peptides,
or small molecules is highly preferred.
4. Instrument Operation: Proficient in operating Prep-HPLC, Flash, LC-MS, protein purification systems, and other related equipment.
5. Analytical Testing: Familiar with biological/chemical analytical testing methods (e.g., LC-MS/TOF/Q-TOF, HPLC, UPLC, GC). Ability to independently design experimental protocols and execute projects.
6. Structural Elucidation: Familiar with common structural identification methods (e.g., IR, HR-MS, NMR), and capable of analyzing target products and impurities.
III. Comprehensive Qualities & Soft
Skills
1. Strong project management skills, sense of responsibility, teamwork, innovation, and strict confidentiality awareness.
2. Excellent communication and coordination skills, with a solid command of English.
3. Honest, diligent, and highly self-motivated with strong execution ability. Capable of undertaking challenges, managing stress effectively, and adapting to a fast-paced, high-pressure work environment.
4. Strictly adhere to relevant safety regulations and policies.