锦鲤求职岗位描述
SUMMARY AND KEY
ACCOUNTIBILITIES:
WuXiBiologics Protein
Analytical Chemistry group is seeking a skilled and highly motivated candidate
to fill a Sr. Scientist to director level position (depending on candidate’s
experience) within Protein Science department in Shanghai/Chengdu. This
position will work collaboratively in cross-functional teams on a range of
programs from research protein generation to next generation technology drug
discovery initiatives. The candidate will work in a highly collaborative
environment to utilize skills in partnership with internal and external
experts.
l Oversee all aspects of
structural characterization work of protein therapeutics, including but not
limited to SEC, IEX, titer, CE-SDS, icIEF, mass spectrometry
l Develop and implement novel
LC-MS based analytical methods to support in-depth characterization of
biologics and other new modalities (AAV, mRNA, oligonucleotide etc), including
but not limited to intact mass, cIEF-MS, peptide mapping, disulfide mapping and
glycan analysis
l Support technical transfer,
training and trouble-shooting of protein engineering and production for R&D
purposes, including but not limited to protein engineering for therapeutic
proteins, humanization and affinity maturation of antibodies and developability
assessment
REQUIREMENTS:
You love analytics and are
passionate about using data to drive key business decisions. You love learning
new technological skills and working through collaboration. You will provide
expertise in the field of in-depth protein analysis as it pertains to biologics
characterization and other novel therapy related work with possibility to
support other modalities as opportunities arise.
l Direct expertise in mass
spec-based proteomics (DDA, MRM, PRM et al.) or protein characterization is
required. Previous experience in quantitative analysis of protein therapeutics
and biomarker candidates by proteomic approach and immunoaffinity enrichment
coupled with LC-PRM/MRM mass spectrometry is preferred.
l In-depth knowledge and
hands-on experience in different types of analytical separation techniques and
data processing analyses with focus on mass spectrometry applications.
l Knowledge of other
analytical techniques such as chromatography (HPLC/UPLC), electrophoresis
(CE-SDS, icIEF), biophysical methods and DNA analysis
l Broad expertise and
familiarity with protein and antibody production, drug discovery and early CMC
development
l Thorough understanding of
biochemistry, structural biology and biologics discovery
l Strong problem-solving and
troubleshooting skills, capabilities in experimental design and execution,
ability to work on multiple projects simultaneously, as well ability to work
independently and collaborate cross-functionally
EDUCATION (Indicate the mini.
requirement & preferred discipline):
l Major：Analytical
chemistry/ Biochemistry/Biophysics/Protein Chemistry, or related field
OTHER SKILLS, ABILITIES &
EXPERIENCE:
l Good communication skills
required, speaks fluent English
l Strong team-working spirit