锦鲤求职岗位描述
SUMMARY
AND KEY ACCOUNTIBILITIES:
Oversee
all aspects of structural characterization work of protein therapeutics,
including but not limited to SEC, IEX, titer, CE-SDS, icIEF, mass
spectrometry.
Develop
and implement novel LC-MS based analytical methods to support in-depth
characterization of biologics and other new modalities (AAV, mRNA,
oligonucleotide etc), including but not limited to intact mass, cIEF-MS,
peptide mapping, disulfide mapping and glycan analysis.
Support
technical transfer, training and trouble-shooting of protein production
for CMC development purposes.
REQUIREMENTS:
You love analytics and
are passionate about using data to drive key business decisions. You love
learning new technological skills and working through collaboration. You will
provide expertise in the field of in-depth protein analysis as it pertains to
biologics characterization and other novel therapy related work with
possibility to support other modalities as opportunities arise.
Direct
expertise in protein characterization or in mass spec-based proteomics
(DDA, MRM, PRM et al.) is required. Previous experience in protein
characterization of biologics and/or glycoproteins using peptide mapping,
intact protein analysis is preferred.
In-depth
knowledge and hands-on experience in different types of analytical
separation techniques and data processing analyses with focus on mass
spectrometry applications.
Knowledge
of other analytical techniques such as chromatography (HPLC/UPLC),
electrophoresis (CE-SDS, icIEF), biophysical methods and DNA analysis.
Broad
expertise and familiarity with protein, antibody production and CMC development.
Thorough
understanding of biochemistry and structural biology.
Strong
problem-solving and troubleshooting skills, capabilities in experimental
design and execution, ability to work on multiple projects simultaneously,
as well ability to work independently and collaborate cross-functionally.